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3.2.3 Treatment of pulmonary diseases Idiopathic pulmonary fibrosis is a chronic and progressive interstitial lung disease characterized by excessive fibrosis of the lung tissue and is associated with high morbidity and mortality rates (Blackwell et al., 2014)

Despite their clinical significance, their use in anticancer therapies is limited due to negative consequences, such as dose-limiting toxicities and drug resistance in the case of type I inhibitors [75]and the development of secondary malignancies when treated with type II inhibitors [76] (Fig

The tissue sections from all experimental groups were dewaxed and hydrated (Alomar et al., 2021)

Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G